Ingredient – Next Generation -Peptides

Next Generation Peptides

Next Generation Peptides : Active Components for Healthy, Young-looking Skin

The proteins present in our skin are responsible for a firm, supple, smooth and youthful looking skin. But with age, these protein structures collapse. This creates a void which creates unevenness. This is what we call fine lines and wrinkles. Collagen is one of the proteins responsible to keep our skin firm and smooth. Another major protein is Elastin, which keeps skin elastic and supple. Without these two proteins, the skin begins to sag, causing wrinkles r and the skin looks crepey.

And that’s where the Next Generation of peptides are useful to reverse this process.

What are Next Gen Peptides?

Peptides are small bonds made of amino acid molecules. These peptides, when chained together, make up protein structures of Collagen and Elastin. When peptide bonds break, the protein structure begins to collapse. This leads to fine lines and wrinkles. With passage of time, the skin appears lose and saggy.

Developments and discoveries in skin sciences have led to the synthesis of various compounds. These bio-compounds can stem the degradation or even reverse it. Here at Bee Elite Essentials we have chosen a few of such next generation ingredients that have shown great promise.

Argireline*

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First of these Next-Generation Peptides is Argireline. It is an effective alternative to botulinum toxin for reducing the number of fine lines and wrinkles.

Argireline, chemically known as Acetyl Hexapeptide-8, is a synthetic peptide that replicates the N-terminal end of SNAP-25. Like this, Argireline competes with it to gain a position in the SNARE complex. This next-generation peptide, Argireline is an effective alternative to botulinum toxin for reducing the number of fine lines and wrinkles.

As we know, fine lines and wrinkles are one of the most prominent signs of skin aging. They can be a result of natural aging or can occur due to premature skin aging caused by environmental stressors or regular muscle movements and muscle contractions. The vesicle in the motor neuron releases neurotransmitters resulting in muscle contractions.

Argireline mimics the N-terminal end of the SNAP-25 to compete with the natural protein for the position in the SNARE complex. This process destabilizes the SNARE complex and the vesicle is unable to release neurotransmitters efficiently. It results in decreased muscle contractions effectively reducing fine lines and wrinkles.

Relistase*

Relistase or Acetyl Aginyltryptophyl Diphenylglycine, as it is chemically known, is a tetrapeptide that works to inhibit elastase activity. Elastase is an enzyme that breaks down the protein for better digestion but this also means that it destroys the elastin present in our skin leading to saggy loose skin and wrinkle formation. Relistase stimulates the collagen production in our skin so as to increase tightness and elasticity in our skin.

Both, normal or premature aging, lead to activate proteolytic degradation of collagen and elastin through elastase and other proteases in our body. This results in the slow down of processes of collagen synthesis and elastogenesis. The elastic fibers are important elements of connective tissues and they provide tensile strength to our skin. These elastic fibers are necessary so that our skin tissues are able to resist skin stretching and gain back its original form without sagging and wrinkles.

The next-generation peptide Relistase curbs the elastase activity and increases resiliency in our skin. It increases collagen I production and improves elastic resistance.

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Reproage*

Artistic Representation only

Reproage or Acetyl Hexapeptide-8 is a hexapeptide that regulates the miR-145 levels in our skin to moderate epidermal cell differentiation. Studies suggest that it may also help in cell reprogramming that can increase skin radiance and improve skin complexion to make it younger.

The basal cells in the epidermis escalate in number and give rise to cells that undergo the process of cell differentiation into mature keratinocytes. In these basal cells, the transcription factors that are the markers of stem cells only have the capacity to replenish mature tissues. These markers are regulated by the microRNAs at the epigenetic level. As we age, these miRs suppress the stem cell markers which causes the basal cells to stop dividing and start differentiating.

Next-generation peptide Reproage reduces the miR-145 levels to increase the level of transcription factors of basal cells. This process reactivates the epidermal pool of progenitors.

The change results in an improvement in skin properties making it visibly smoother, rejuvenated, and radiant.